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Powers Group

Publications

2024

• S. Lei, A. Anandhan, J. Li, R. Grealish, R. Powers* and R. Franco* (2024) Impairment of Energy/Glucose Metabolism by α-Synuclein Potentiates Manganese Toxicity, J. Neurochem, in preparation.
• F. Bhinderwala, T. Gebregiworgis, J. Souchek, N. Chaika, V. Purohit, P. K. Singh, and R. Powers* (2024) Metabolic analyses of crosstalk between pancreatic stromal and cancer cells, , in preparation.
• S. Li, F. Bhinderwala, D. G. Beltran, C. Zhang, R. Powers*, and L. Zhang* (2024) Insights into the Function of the Novel Transcription Factor WhiB1 from Mycobacteria, , in preparation.
• T. Vu, C. P. Jurich, M. J. Jeppesen, I. T. Sakallioglu, I. Arslan, D. Feng, P. Siemek, B. Worley, J. D. Yesselman, and R. Powers* (2024) MVAPACK v.2: a complete data handling package for NMR and MS metabolomics, , in preparation.
• M. J. Jeppesen,I. Arslan, D. Feng, P. Siemek, C. P. Jurich, I. T. Sakallioglu, J. D. Yesselman, and R. Powers* (2024) MVAPACK: An Online Platform for NMR and GC/LC-MS Metabolomics Data Processing and Statistical Analysis, , in preparation.
• D. Cochran, P. G. Takis,* J. L. Alexander, B. J. Mullish, N. Powell, J. R. Marchesi and Robert Powers* (2024) Evaluation of Protein Precipitation Methods for NMR Serum Metabolomics, Analytical Chemistry, in preperation.
• A. A. Crook, J. Rose, A. Anandhan, C. Brian, R. Powers*, and R. Franco* (2024) Mitochondrial metabolism in astrocytes is essential for their survival against neurotoxic electrophile exposure, Journal of Neuroscience Research, in revision.
• E. Przygrodzka, F. Binderwala, R. Powers, R. M. McFee, A. S. Cupp, J. R. Wood, J. S. Davis (2024) Central Role for Glycolysis and Fatty Acids in LH-responsive Progesterone Synthesis, PNAS, submitted.
• D. Cochran, M. NourEldein, D. Bezdekova, and R. Powers* (2024) A Reproducibility Crisis for Clinical Metabolomics Studies, PNAS, submitted.
• C. P. Jurich, M. J. Jeppesen, I. T. Sakallioglu, A. De Lima Leite, J. D. Yesselman,* and R. Powers* (2024) A simulated LC-MS dataset for assessing the metabolomics data processing pipeline implemented into MVAPACK, Analytical Chemistry, in revision.
• M. Behounek, D. Cochran, H. A. Motta-Romero, Q. Yang, M. Morton, K. Majumder, R. Powers, D. J. Rose* (2024) In vitro fermentation of animal and plant protein isolates by the human gut microbiota under high and low carbohydrate condition, Molecular Nutrition and Food Research, in revision.
• (195) S. T. Ovbude, S. Sharmeen, I. Kyei, H. Olupathage, J. Jones, R. J. Bell, R. Powers, and D. S. Hage (2024) "Applications of Chromatographic Methods in Metabolomics: A Review", Journal of Chromatography B, 1239:124124; https://doi.org/10.1016/j.jchromb.2024.124124.
• (194) H. E. Roth, F. Bhinderwala, M. Filipi, S. Jack, and R. Powers* (2024) "Potential Metabolite Biomarkers of Multiple Sclerosis from Multiple Biofluids", ACS Chemical Neuroscience, 15(6):1110-1124; https://doi.org/10.1021/acschemneuro.3c00678.
• (193) D. Murthy, K. S. Attri, S. K. Shukla, R. Thakur, N. V. Chaika, C. He, D. Wang, K. Jha, A. Dasgupta, R. J. King, S. E. Mulder, J. Souchek, T. Gebregiworgis, V. Rai, R. Patel, T. Hu, S. Rana, S. S. Kollala, C. Pacheco, P. M. Grandgenett, F. Yu, V. Kumar, A. J. Lazenby, A. R. Black, S. Ulhannan, A. Jain, B. H. Edil, D. L. Klinkebiel, R. Powers, A. Natarajan, M. A. Hollingsworth, K. Mehla, Q. Ly, S. Chaudhary, R. F. Hwang, K. E. Wellen, and P. K. Singh* (2024) "Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis", Nature Cell Biology, 26,613-627;https://doi.org/10.1038/s41556-024-01372-4.
• (192) G. J. Gouveia, T. Head, L. Cheng, C. S. Clendinen, J. Cort, X. Du, A. Edison, C. Fleischer, J. Hoch, N. Mercaldo, W. Pathmasiri, D. Raftery, T. Schock, J. Shearer, L. Sumner, P. G. Takis, V. Copie,* H. R. Eghbalnia,* and R. Powers* (2024) "Perspective: Use and Reuse of Metabolomics Data: what works and what remains challenging", Metabolomics, 20(41; https://doi.org/10.1007/s11306-024-02090-6.
• (191) R. Powers*, E. R. Andersson, A. L. Bayless, R. B. Brua, M. Chang, L. L. Cheng, C. S. Clendinen, D. Cochran, V. Copie, J. R. Cort, A. A. Crook, H. R. Eghbalnia, A. Giacalone, G. J. Gouveia, J. C. Hoch, M. J. Jeppesen, A. S. Maroli, M. E. Merritt, W. Pathmasiri, H. E. Roth, A. Rushin, I. T. Sakallioglu, S. Sarma, T. B. Schock, L. W. Sumner, P. Takis, M. Uchimiya, and D. S. Wishart (2024) "Best Practices in NMR Metabolomics: Current State", TrAC Trends in Analytical Chemistry, 171, 117478; https://doi.org/10.1016/j.trac.2023.117478; (cover).

2023

• (190) G. A. N. Gowda and R. Powers* (2023) "Editorial: Frontiers in NMR Metabolomics", Magnetic Resonance in Chemistry, 61(12)627; https://doi.org/10.1002/mrc.5400.
• (189) N. Kumar, S. Rachagani, G. Natarajan, A. A. Crook, T. Gopal, J. Kaushal, S. Nagabhishek, R. Powers, S. Batra, and V. Saraswathi* (2023) "Histidine enhances the anticancer effect of gemcitabine against pancreatic cancer via disruption of amino acid homeostasis and oxidant-antioxidant balance", Cancers, 15(9), 2593; https://doi.org/10.3390/cancers15092593 PMC10177467.
• (188) M. J. Jeppesen and R. Powers* (2023) "Multiplatform Untargeted Metabolomics", Magnetic Resonance in Chemistry, 61(12)628-653; https://doi.org/10.1002/mrc.5350; (cover).
• (187) T. Andrews, J. Seravallic, and R. Powers* (2023) "The Reversible Low Temperature Instability of Human DJ-1 Oxidative States", Biopolymers, e23534; https://doi.org/10.1002/bip.23534.
• (186) B. R. Sahoo, A. A. Crook, A. Pattnaik, A. D. Torres-Gerena, O. Khalimonchuk, R. Powers, R. Franco, and A. K. Pattnaik* (2023) "Redox Regulation and Metabolic Dependency of Zika Virus Replication: Inhibition by Nrf2-Antioxidant Response and NAD(H) Antimetabolites", Journal of Virology, 97(2): e01363-22; https://doi.org/10.1128/jvi.01363-22 PMC9972919.
• (185) I. T. Sakallioglu, B. Tripp, J. Kubik, C. A. Casey, P. Thomes, and R. Powers* (2023) "A Multiomics Approach Captures Hepatic Metabolic Network Altered by Chronic Ethanol Administration", Biology, 12(1):28; https://doi.org/10.3390/biology12010028 PMC9855439.

2022

• (184) F. Bhinderwala, H. E. Roth, H. Noel, D. Feng, and R. Powers* (2022) "Chemical Shift Variations in Common Metabolites", Journal of Magnetic Resonance, 345, 107335; https://doi.org/10.1016/j.jmr.2022.107335 PMC974230.
• (183) S. K Shakyawar, N. K Mishra, N. N Vellichirammal, L. Cary, T. Helikar, R. Powers, R. E Oberley-Deegan, D. B Berkowitz, K. W Bayles, V. K Singh, C. Guda* (2022) "A review of radiation-induced alterations of multi-omic profiles, radiation biomarkers and countermeasures", Radiation Research, 199(1), 89-111; https://doi.org/10.1667/RADE-21-00187.1 PMC10279411(cover).
• (182) F. Bhinderwala, T. Vu, T. Smith, J. Kosacki, D. D. Marshall,Y. Xu, M. Morton, and R. Powers* (2022) "Leveraging the HMBC to Facilitate Metabolite Identification", Anal. Chem., 94(47),16308-16318; https://doi.org/10.1021/acs.analchem.2c02902.
• (181) I. T. Sakallioglu, A. S. Maroli, A. L. Leite, D. Marshall, B. W. Evans, E. K. Zinniel, P. H. Dussault, R. G. Barletta, and R. Powers* (2022) "A Multiomics Investigation into the Mechanism of Action of an Anti-Tubercular Fatty Acid Analog", J. Am. Chem. Soc., 144(46), 21157-21173; https://doi.org/10.1021/jacs.2c08238.
• (180) H. E. Roth, A. L. Leite, N. Y. Palermo, and R. Powers* (2022) "Leveraging the Structure of DNAJA1 to Discover Novel Potential Pancreatic Cancer Therapies", Biomolecules, 12(10), 1391; https://doi.org/10.3390/biom1210139 PMC9599757.
• (179) H. E. Roth and R. Powers* (2022) "Meta-analysis Reveals Both the Promises and the Challenges of Clinical Metabolomics", Cancers, 14(16),3992; https://doi.org/10.3390/cancers14163992 PMC9406125.
• (178) D. S. Wishart*, L. L. Cheng, V. Copie, A. S. Edison, H. R. Eghbalnia, J. C. Hoch, G. J. Gouveia, W. Pathmasiri, R. Powers* T. B. Schock, L. W. Sumner,* and M. Uchimiya (2022) "NMR and Metabolomics-A Roadmap for the Future", Metabolites, 12(8):678. https://doi.org/10.3390/metabo12080678 PMC9394421.
• (177) M. S. R. Abid, B. A. Tripp, H. Qiu, A. L. Leite, H. E. Roth, S. Sharma, J. Adamec, R. Powers* and J. W. Checco* (2022) "Peptidomics analysis reveals changes in small urinary peptides in patients with interstitial cystitis/bladder pain syndrome", Scientific Reports, 12:8289 https://doi.org/10.1038/s41598-022-12197-2 PMC9117215.
• (176) G. A. Somerville*, A. A. Parrett, J. M. Reed, S. G. Gardner, and R. Powers* (2022) "Human Serum Alters the Metabolism and Antibiotic Susceptibility of Staphylococcus aureus", Journal of Proteome Research, 21(6):1467-1474; https://doi.org/10.1021/acs.jproteome.2c00073.
• (175) T. Vu, Y. Xu*, Y. Qiu and R. Powers* (2022) "Shifting-corrected regularized regression for ¹H NMR metabolomics identification", Biostatistics, kxac015, https://doi.org/10.1093/biostatistics/kxac015 PMC9748598.
• (174) A. Chatterjee, I. T. Sakallioglu, D. Murthy, E. A. Kosmacek, P. K. Singh, J. T. McDonald, R. Powers, and R. E. Oberley-Deegan* (2022) "MnTE-2-PyP protects mitochondria in hyperglycemic and irradiated prostate fibroblasts", Redox Biology, 52, 102301; https://doi.org/10.1016/j.redox.2022.102301 PMC8967707.
• (173) I. T. Sakallioglu, A. S. Maroli, A. L. Liete, and R. Powers* (2022) "A Reverse Phase UPLC-MS^E Method for Rapid Identification of Mycobacterial Lipids", Journal of Chromatography A, 1662, 462739; https://doi.org/10.1016/j.chroma.2021.462739 PMC880528.
• (172) H. Zhao, Y. Zhan, Z. Xu, J. J. Nduwamungu, Y. Zhou, R. Powers, C. Xu* (2022) "The Application of Machine-Learning and Raman Spectroscopy for the Rapid Detection of Edible Oils Type and Adulteration", Food Chemistry, 373(Part B):131471; https://doi.org/10.1016/j.foodchem.2021.131471 Link to Spotlight interview on Spectroscopy Online.

2021

• (171) Y. Pustovalova, F. Delaglio, D. L. Craft, H. Arthanari, A. Bax, M. Billeter, M. J. Bostock, H. Dashti, D. F. Hansen, S. G. Hyberts, B. A. Johnson, K. Kazimierczuk, H. Lu, M. Maciejewski, T. Miljenovic, M. Mobli, D. Nietlispach, V. Orekhov, R. Powers, X. Qu, S. A. Robson, D. Rovnyak, G. Wagner, J. Ying, M. Zambrello, J. C. Hoch, D. L. Donoho, and A. D. Schuyler (2021) "NUScon: A community-driven platform for quantitative evaluation of nonuniform sampling in NMR", Magnetic Resonance, 2, 843-861; https://doi.org/10.5194/mr-2-843-2021 PMC10583271.
• (170) A. N. Pachikov, R. R. Gough, C. E. Christy, M. E. Morris, C. A. Casey, C. A. LaGrange, G. Bhat, A. V. Kubyshkin, I. I. Fomochkina, E. Y. Zyablitskaya, T. P. Makalish, E. P. Golubinskaya, S. N. Eremenko, J.-J. M. Riethoven, A. S. Maroli, T. S. Payne, R. Powers, A. Y. Lushnikov, A. J. Macke and A. Petrosyan* (2021) "The non-canonical mechanism of ER stress-mediated progression of prostate cancer ", Journal of Experimental & Clinical Cancer Research, 40(1):289; https://doi.org/10.1186/s13046-021-02066-7/ PMC8439065.
• (169) I. T. Sakallioglu, R. G. Barletta, P. H. Dussault, and R. Powers* (2021) "Deciphering the Mechanism of Action of Anti-Tubercular Compounds with Metabolomics", Computational and Structural Biotechnology Journal, 19:4284-4299; https://doi.org/10.1016/j.csbj.2021.07.034 PMC8358470.
• (168) A. A. Crook, A. L. Leite, T. Payne, F. Bhinderwala, J. Woods, V. K. Singh, and R. Powers* (2021) "Radiation Exposure Induces Cross-Species Temporal Metabolic Changes that are Mitigated in Mice by Amifostine", Scientific Reports, 11,14004; https://doi.org/10.1038/s41598-021-93401-7 PMC8263605.
• (167) C. Honrao, N. Teissier, B. Zhang, R. Powers* and E. M. O´Day* (2021) "Gadolinium-based Paramagnetic Relaxation Enhancement Agent Enhances Sensitivity for NUS Multidimensional NMR-based Metabolomics", Molecules, 26(17):5115; https://doi.org/10.3390/molecules26175115 PMC8433644.
• (166) A. S. Maroli* and R. Powers* (2021) "Closing the gap between in vivo and in vitro omics: using QA/QC to strengthen ex vivo NMR metabolomics", NMR in Biomedicine, e4594; https://doi.org/10.1002/nbm.4594 PMC8821733.
• (165) H. E. Roth, F. Bhinderwala, R. Franco, Y. Zhou, and R. Powers* (2021) "DNAJA1 dysregulates metabolism promoting an anti-apoptotic phenotype in pancreatic ductal adenocarcinoma", Journal of Proteome Research, 20(8):3925-3939; https://doi.org/10.1021/acs.jproteome.1c00233 PMC8823314Featured in Medicine Innovates.
• (164) A. A. Crook, D. Zamora-Olivares, F. Bhinderwala, J. Woods, M. Winkler, S. Rivera, C. E. Shannon, H. R. Wagner, D. L. Zhuang, J. E. Lynch, N. R. Berryhill, R. C. Runnebaum, E. Anslyn, and R. Powers* (2021) "Combination of Two Analytical Techniques Improves Wine Characterization by Vineyard, Region, and Vintage", Food Chemistry, 354,129531; https://doi.org/10.1016/j.foodchem.2021.129531 PMC8336071.
• (163) R. Moore, T. Helikar, B. L. Puniya, R. Powers, B. Guda, K. W Bayles, and D. Berkowitz (2021) "Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome", Scientific Reports, 11,5585; https://doi.org/10.1038/s41598-021-85044-5 PMC7946886.
• (162) R. Poudel, F. Bhinderwala, M. Morton, R. Powers*, and D. J. Rose* (2021) "Metabolic Profiling of Historical and Modern Wheat Cultivars using Proton Nuclear Magnetic Resonance Spectroscopy", Scientific Reports, 11,3080; https://doi.org/10.1038/s41598-021-82616-3 PMC7862595.

2020

• (161) A. A. Crook and R. Powers* (2020) "Quantitative NMR-based Biomedical Metabolomics: Current Status and Applications", Molecules, 25(21),5128; https://doi.org/10.3390/molecules25215128 PMC7662776.
• (160) J. L. Catlett, J. Catazaro, M. Cashman, S. Carr, R. Powers, M. B. Cohen, and N. B. Buan* (2020) "Metabolic Feedback Inhibition Influences Metabolite Secretion by the Human Gut Symbiont Bacteroides thetaiotaomicron", mSystems, 5(5),e00252-20; https://doi.org/10.1128/mSystems.00252-20 PMC7470985.
• (159) B. Zhang, R. Powers, and E. M. O´Day* (2020) "Evaluation of Non-Uniform Sampling 2D ¹H-¹³C HSQC Spectra for Semi-Quantitative Metabolomics", Metabolites, 10(5),203; https://doi.org/10.3390/metabo10050203 PMC7281502.
• (158) F. Bhinderwala, P. Evans, K. Jones, B. R. Laws, T. G. Smith, M. Morton, and R. Powers* (2020) "Phosphorus NMR and Its Application to Metabolomics", Anal. Chem., 92(14):9536-9545 PMC8327684.
• (157) A. Parrett, J. M. Reed, S. G. Gardner, N. N. Mishra, A. S. Bayer, R. Powers*, and G. A. Somerville* (2020) "Metabolic Changes Associated with Adaptive Resistance to Daptomycin in Streptococcus mitis-oralis", BMC Microbiology, 20, 162; https://doi.org/10.1186/s12866-020-01849-w PMC7296729.

2019

• (156) D. K. Zinniel, W. Sittiwong, D. D. Marshall, G. Rathnaiah, I. T. Sakallioglu, R. Powers, P. H. Dussault and R. G. Barletta* (2019) "Novel Amphiphilic Cyclobutene and Cyclobutane cis-C₁₈ Fatty Acid Derivatives Inhibit Mycobacterium avium subsp. paratuberculosis Growth", Veterinary Sciences, 6(2):46 PMC6631517.
• (155) T. Vu, P. Siemek, F. Bhinderwala, Y. Xu and R. Powers* (2019) "Evaluation of Multivariate Classification Models for Analyzing NMR Metabolomics Data", J. Proteome Res., 18(9):3282-3294 PMC6733656.
• (154) K. Bahmed, S. Boukhenouna, L. Karim, T. Andrews, J. Lin, R. Powers, M. A. Wilson, C.-R. Lin, E. Messier, N. Reisdorph, R. L. Powell, H.-Y. Tang, R. J. Mason, G. J. Criner and B. Kosmider* (2019) "The effect of cysteine oxidation on DJ-1 cytoprotective function in human alveolar type II cells", Cell Death & Disease, 10(9):638 PMC6717737.
• (153) F. Bhinderwala and R. Powers* (2019) "NMR Metabolomics Protocols for Drug Discovery", In NMR-Based Metabolomics. Methods in Molecular Biology, Eds. G.A. Nagana Gowda, D. Raftery, Humana Press, New York, Vol. 2037, Chapt. 16, pp. 265-311 PMC7025395.
• (152) F. Bhinderwala, S. Lei, J. Woods, J. Rose, D. D. Marshall, E. Riekeberg, A. L. Leite, M. Morton, E. D. Dodds, R. Franco*, and R. Powers* (2019) "Metabolomic Analyses from Tissues in Parkinson`s Disease", In Metabolomics. Methods in Molecular Biology, Ed. S. Bhattacharya, Humana Press, New York, Vol. 1966, Chapt. 19, pp. 217-257 PMC6625357.
• (151) N. Rodrigues de Almeida, J. Catazaro, M. Krishnaiah, Y. S. Chonker, D. J. Murry, R. Powers*, and M. Conda-Sheridan* (2019) "Understanding Interactions of Citropin 1.1 Analogues with Model Membranes and Their Influence on Biological Activity", Peptides, 119,170119 PMC7161086.
• (150) X. Li, W. Gong, H. Wang, T. Li, L. E. Herring, J. M. Asara, Y. Lei, F. Bhinderwala, R. Powers, R. E. Lewis, K. S. Attri, P. K. Singh, X. Yang, and H. Wen* (2019) "O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting RIPK3", Immunity, 50(3):576-590 PMC6426684.
• (149) J. Catazaro, A. Caprez, D. Swanson and R. Powers* (2019) "Functional Evolution of Proteins", Proteins, 87(6):492-501 PMC6462239.
• (148) C. Zhou, F. Bhinderwala, M. K. Lehman, V. C. Thomas, S. S. Chaudhari, K. J. Yamada, R. Powers, T. L. Kielian, P. D. Fey* (2019) "Urease is an Essential Component of the Acid Response Network of Staphylococcus aureus and is Required for a Persistent Murine Kidney Infection", PLoS Pathogens, 15(1) e1007538 PMC6343930.

2018

• (147) T. Gebregiworgis, F. Bhinderwala, V. Purohit, N. V. Chaika, P. K. Singh, and R. Powers* (2018) "Insights into Gemcitabine Resistance and the Potential for Therapeutic Monitoring", Metabolomics, 14:156 PMC6620022.
• (146) F. Bhinderwala, N. Wase, C. DiRusso, R. Powers* (2018) "Combining Mass Spectrometry and NMR Improves Metabolite Detection and Annotation", J. Proteome Res., 17(11):4017-4022 PMC6668615.
• (145) T. Vu, E. Riekeberg, Y. Qiu and R. Powers* (2018) "Comparing Normalization Methods and the Impact of Noise", Metabolomics, 14:108 PMC6638559.
• (144) F. Bhinderwala, S. Lonergan, J. Woods, C. Zhou. P. Fey, and R. Powers* (2018) "Expanding the Coverage of the Metabolome with Nitrogen-Based NMR", Analytical Chemistry, 90(7):4521-4528 PMC6472702.
• (143) S. G. Gardner, D. D. Marshall, R. S. Daum, R. Powers* and G. A. Somerville* (2018) "Metabolic mitigation of Staphylococcus aureus Vancomycin Intermediate-Level Susceptibility", Antimicrobial Agents and Chemotherapy, 62(1):e01608-17 PMC5740343.
• (142) J. Catazaro, T. Andrews, N. M. Milkovic, J. Lin, A. J. Lowe, M. A. Wilson, and R. Powers* (2018) "¹⁵N CEST Data and Traditional Model-Free Analysis Capture Fast Internal Dynamics of DJ-1", Analytical Biochemistry, 542(1 February 2018):24-28 PMC5817017.

2017

• (141) M. Bernier, J. Catazaro, N. S. Singh, A. Wnorowski, A. Boguszewska-Czubara, K. Jozwiak,R. Powers, and I. W. Wainer* (2017) "GPR55 Receptor Antagonists Decrease Glycolytic Activity in PANC-1 Pancreatic Cancer Cell Lines and Tumor Xenografts", International Journal of Cancer, 141(10):2131-2142 PMC6028007.
• (140) T. Gebregiworgis, V. Purohit, S. K. Shukla, S. Tadros, N. V. Chaika, J. Abrego, S. E. Mulder, V. Gunda, P. K. Singh,* and R. Powers* (2017) "Glucose Limitation Alters Glutamine Metabolism in MUC1 Overexpressing Pancreatic Cancer Cells", J. Proteome Res., 16(10):3536-3546 PMC5634392.
• (139) G. Natarajan, C. Perriotte-Olson, F. Bhinderwala, R. Powers, M. C. Zimmerman, C. V. Desouza, G. Talmon,J. Yuhang, A. V. Kabanov, and V. Saraswathi* (2017) "Nanoformulated Copper/Zinc Superoxide Dismutase Exerts Differential Effects on Glucose Versus Lipid Homeostasis Depending on the Diet Composition Possibly via Altered AMPK Signaling", Transl. Res., 188(October 2017)10-26 PMC5819896.
• (138) J. Rose, Brian, J. Woods, A. Pappa, M. I. Panayiotidis, R. Powers and R. Franco* (2017) "Mitochondrial Dysfunction in Glial Cells: Implications for Neuronal Homeostasis and Survival", Toxicology, 391(1 November 2017):109-115 PMC5661369.
• (137) E. Riekeberg and R. Powers* (2017) "New Frontiers in Metabolomics: From Measurement to Insight[version 1, referees:3 approved]", F1000Research, 6(F1000 Faculty Rev):1148 PMC5521158.
• (136) S. K. Shukla, V. Purohit, K. Mehla, V. Gunda, N. V. Chaika, E. Vernucci, R. J. King, J. Abrego, G. D. Goode, A. Dasgupta, A. L Illies, T. Gebregiworgis, B. Dai, J. J. Augustine, D. Murthy, K. S. Attri, O. Mashadova, P. M. Grandgenett, R. Powers, Q. P. Ly, A. J. Lazenby, J. L. Grem, F. Yu, J. M. Mates, J. M. Asara, J.-w. Kim, J. H. Hankins, C. Weekes, M. A. Hollingsworth, N. J. Sarkova, A. R. Sasson, J. B. Fleming, J. M. Oliveto, C. A. Lyssiotis, L. C. Cantley, L. Berim, and P. K. Singh* (2017) "MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance in Pancreatic Cancer", Cancer Cell, 32(1):71-87 PMC5533091.
• (135) S. S. Chaudhari, M. Kim, S. Lei, F. Razvi, A. Alqarzaee, E. Hutfless, R. Powers, P. Fey, V. C. Thomas* (2017) "Nitrite Derived from Endogenous Bacterial Nitric Oxide Synthase Activity Promotes Aerobic Respiration", mBio, 8(4):e00887-17 PMC5539425.
• (134) R. Powers*, S. Lei, A. Anandhan, D. D. Marshall, B. Worley, R. L. Cerny, E. D. Dodds, Y. Huang, M. I. Panayiotidis, A. Pappa, R. Franco* (2017) "Metabolic Investigations of Molecular Mechansims Associated with Parkinson`s Disease", Metabolites, 7(2):22 PMC5487993.
• (133) A. Anandhan, M. S. Jacome, S. Lei, P. Hernandez-Franco, A. Pappa, M. I. Panayiotidis, R. Powers and R. Franco* (2017) "Metabolic Dysfunction in Parkinson`s Disease: Bioenergetics, Redox Homeostasis, and Central Carbon Metabolism", Brain Research Bulletin, 133:12-30 PMC5555796.
• (132) J. Catazaro, J. Periago, M. Shortridge, B. Worley, A. Kirchner, R. Powers* and M. A. Griep* (2017) "Identification of a Ligand Binding Site on the Staphylococcus aureus DnaG primase C-Terminal Domain.", Biochemistry, 56(7):932-943 PMC6476306.
• (131) D. D. Marshall, S. Halouska, D. K. Zinniel, R. J. Fenton, K. Kenealy, H. K. Chahal, G. Rathnaiah, R. G. Barletta*, R. Powers* (2017) "Assessment of Metabolomic Changes in Mycobacterium smegmatis Wild Type and alr Mutant Strains: Evidence for a New Pathway of D-Alanine Biosynthesis", J. Proteome Res., 16(3):1270-1279 PMC65999645.
• (130) C. R. Halsey, S. Lei, J. Wax, M. K. Lehman, A. S. Nuxoll, L. Steinke, M. Sadykov, R. Powers* and P. D. Fey* (2017) "Amino Acid Catabolism in Staphylococcus aureus and the Function of Carbon Catabolite Repression", mBio, 8(1):e10434-16 PMC5312079.
• (129) D. D. Marshall and R. Powers* (2017) "Beyond the Paradigm: Combining Mass Spectrometry and Nuclear Magnetic Resonance for Metabolomics", Progress in Nuclear Magnetic Resonance Spectroscopy, 100(May 2017):1-16 PMC5448308.
• (128) J. L. Markley,* R. Bruschweiler, A. S. Edison, H. Eghbalnia, R. Powers, D. Raftery, D. S. Wishart (2017) "The future of NMR-based Metabolomics", Current Opinion in Biotechnology, 43(February 2017):34-40 PMC5305426.
• (127) J. Catazaro, A. J. Lowe, R. L. Cerny, and R. Powers* (2017) "The NMR Solution Structure and Function of RPA3313: A Hypothetical Protein from R. palustris", Proteins, 85(1):93-102 PMC5167650.
• (126) A. Anandhan, S. Lei, R. Levytskyy, A. Pappa, M. I. Panayiotidis, R. L. Cerny, O. Kalimonchuk, R. Powers* and R. Franco* (2017) "Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by gene (α-synuclein)-Envronment(paraquat) Interactions", Molecular neurobiology, 54(5):3825-3842 PMC5173445.

2016

• (125) D. D. Marshall, M. R. Sadykov, V. C. Thomas, K. W. Bayles, and R. Powers* (2016) "Redox Imbalance Underlies the Fitness Defect Associated with Inactivation of the Pta-AckA Pathway in Staphylococcus aureus", J. Proteome Res., 15(4):1205-1212 PMC4875753.
• (124) B. Worley and R. Powers* (2016) "PCA as a Predictor of OPLS-DA Model Reliability", Current Metabolomics, 4(2):97-103 PMC4990351.
• (123) T. Gebregiworgis, H. H. Nielsen, C. Massilamany, A. Gangaplara, J. Reddy, Z. L. Illes, and R. Powers* (2016) "A Urinary Metabolic Signature for Multiple Sclerosis and Neuromyelitis Optica", Journal of Proteome Research, 15(12):659-666 PMC4772670.
• (122) J. Everett, R. Tejero, S. B. K., Murthy, T. B. Acton, J. M. Aramini, M. C. Baran, J. Benach, J. R. Cort, A. Eletsky, F. Forouhar, R. Guan, A. P. Kuzin, H.-W. Lee, G. Liu, R. Mani, B. Mao, J. L. Mills, A. F. Montelione, K. Pederson, R. Powers, T. Ramelot, P. Rossi, J. Seetharaman, D. Snyder, G. V. T. Swapna, S. M. Vorobiev, Y. Wu, R. Xiao, Y. Yang, C. H. Arrowsmith, J. Hunt, M. A. Kennedy, J. Prestegard, T. Szyperski, L. Tong, and G. T. Montelione (2016) "A Community Resource of Experimental Data for NMR - X-ray Crystal Structure Pairs", Protein Science, 25(1):30-45 PMC4815321.

2015

• (121) B. Worley and R. Powers* (2015) "A Sequential Algorithm for Multiblock Orthogonal Projections to Latent Structures", Chemometr. Intell. Lab. Syst., 149(Part B):33-39 PMC4668594.
• (120) N. M. Milkovic, J. Catazaro,, J. Lin, S. Halouska, J. L. Kizziah,S. Basiaga, R. L. Cerny, R. Powers, and M. A. Wilson* (2015) "Transient Sampling of Aggregation-prone Conformations Causes Pathogenic Instability of a Parkinsonian Mutant of DJ-1 at Physiological Temperature", Protein Science, 24(10):1671-1685 PMC4594666.
• (119) B. Worley, and R. Powers* (2015) "Deterministic Multidimensional Nonuniform Gap Sampling", J. Mag. Res., 261(December 2015):19-26 PMC4970466.
• (118) B. Worley, N. J. Sisco, and R. Powers* (2015) "Statistical Removal of Background Signals from High-Throughput ¹H NMR line-broadening Ligand-Affinity Screens", J. Biomol. NMR, 63(1):53-58 PMC4577452.
• (117) R. Gaupp, S. Lei, J. M. Reed, S. Boyle-Vavra, A. S. Bayer, M. Bischoff, M. Herrmann, R. S. Daum, R. Powers*, and G. A. Somerville* (2015) "Staphylococcus aureus metabolic adaptions during transition from a daptomycin susceptible phenotype to a daptomycin non-susceptible phenotype", Antimicrobial Agents and Chemotherapy, 59(7):4226-4238 PMC4468685.
• (116) B. Worley, and R. Powers* (2015) "Generalized Adaptive Intelligent Binning of Multiway Data", Chemometr. Intell. Lab. Syst., 146:42-46 PMC4456038.
• (115) D. D. Marshall, S. Lei, B. Worley, Y. Huang, A. Garcia-Garcia, R. Franco, E. D. Dodds*, and R. Powers* (2015) "Combining DI-ESI-MS and NMR Datasets for Metabolic Profiling", Metabolomics, 11(2):391-402 PMC4354777.

2014

• (114) J. Catazaro, A. Caprez, A. Guru, D. Swanson, and R. Powers* (2014) "Functional Evolution of PLP-dependent Enzymes based on Active-Site Structural Similarities", Proteins, 82(10):2597-2608 PMC4177364 (cover).
• (113) W. Sittiwong, D. K. Zinnel, R. J. Fenton, D. D. Marshall, C. F. Story, R. Powers, R. G. Barletta, and P. H. Dussault (2014) "Development of Cyclobutene- and Cyclobutane-Functionalized Fatty Acids with Inhibitory Activity against Mycobacterium tuberculosis ", ChemMedChem, 9(8):1838-1849 PMC4142477.
• (112) S. K. Shukla,T. Gebregiworgis, V. Purohit, N. V. Chaika, R. Powers, F. Yu. and P. K. Singh* (2014) "Metabolic Reprogramming Induced by Ketone Bodies Diminishes Pancreatic Cancer Cachexia.", Cancer & Metabolism, 2:18 PMC4165433.
• (111) B. Worley and R. Powers* (2014) "MVAPACK: A Complete Data Handling Package for NMR Metabolomics", ACS Chem. Biol., 9(5):1138-1144 PMC4033658.
• (110) R. Powers* (2014) "The Current State of Drug Discovery and a Potential Role for NMR Metabolomics", J. Med. Chem., 57(14):5860-5870 PMC4324437.
• (109) N. Ledala, B. Zhang, J. Seravalli, R. Powers,G. A. Somerville* (2014) "Influence of Iron and Aeration on Staphylococcus aureus Growth, Metabolism, and Transcription", J. Bacteriol., 196(12):2178-2189 PMC4054190.
• (108) J. L. Stark, J. C. Copeland, A. Eletsky, G. A. Somerville, T. Szyperski, R. Powers* (2014) "Identification of Low Molecular Weight Compounds Inhibiting Growth of Corynebacteria: Potential Lead Compounds for Antibiotics", ChemMedChem, 9(2):282-285 PMC3977743.
• (107) S. Lei, L. Zavala-Flores, A. Garcia-Garcia, R. Nandakumar, N. Madayiputhiya, Y. Huang, E. D. Dodds,R. C. Stanton, R. Powers*, and R. Franco* (2014) "Alterations in Energy/Redox Metabolism Induced by Mitochondrial and Environmental Toxins: A Specific Role for Glucose-6-Phosphate-Dehydrogenase and the Pentose Phosphate Pathway in Paraquat Toxicity", ACS Chem. Biol., 9(9):2032-2048 PMC4168797.
• (106) J. L. Stark, K. Mehla, N. Chaika, T. B. Acton, R. Xiao, P. K. Singh, G. T. Montelione, and R. Powers* (2014) "The Structure and Function of Human DNAJ Homologue Subfamily A Member 1 (DNAJA1) and Its Relationship to Pancreatic Cancer", Biochemistry, 53(8):1360-13729 PMC3985919.
• (105) S. Halouska, R. J. Fenton, D. K. Zinniel, D. D. Marshall, R. G. Barletta* and R. Powers* (2014) "Metabolomics Analysis Identifies D-Alanine-D-alanine Ligase as the Primary Lethal Target of D-cycloserine in Mycobacteria", J. Proteome Res., 13(2):1065-1076 PMC3975674.
• (104) G. A. Somerville and R. Powers (2014) "Growth and Preparation of Staphylococcus epidermidis for NMR Metabolomic Analysis", In Methods in Molecular Biology, Ed. P. Fey, Humana Press, New York, Vol. 1106, pp. 71-91.
• (103) B. Worley and R. Powers* (2014) "Simultaneous Phase and Scatter Correction for NMR Datasets", Chemometr. Intell. Lab. Syst., 131(2014):1-6 PMC3907089.

2013

• (102) S. Halouska and R. Powers* (2013) "NMR in Drug Discovery - Introduction", Encyclopedia of Biophysics, 3:1713-1724.
• (101) T. Hartmann, B. Zhang, G. Baronian, B. Schulthess, D. Homerova, S. Grubmullera E. Kutzner, R. Gaupp, R. Bertram, R. Powers, W. Eisenreich, J. Kormanec, M. Hermann, V. Molle, G. A. Somerville and M. Bischof (2013) "Catabolite Control Protein E (CcpE) is a LysR-type Transcriptional Regulator of Tricarboxylic Acid Cycle Activity in Staphylococcus aureus", J. Biol. Chem, 288(50):36116-36128 PMC3861659.
• (100) S. Halouska, B. Zhang, R. Gaupp, S. Lei, E. Snell, R. J. Fenton, R. G. Barletta, G. A. Somerville, and R. Powers* (2013) "Revisiting Protocols for the NMR Analysis of Bacterial Metabolomes", Journal of Integrated OMICS, 3(2):120-137 PMC4465129.
• (99) S. Lei and R. Powers* (2013) "NMR Metabolomics Analysis of Parkinson`s Disease", Current Metabolomics, 1(3):191-209 PMC4465192.
• (98) M. Sadykov, V. Thomas, D. Marshall, C. Wenstrom, D. Moormeier, T. Widhelm, A. Nuxol, R. Powers and K. Bayles (2013) "Inactivation of the Pta-AckA Pathway Causes Cell Death in Staphylococcus aureus", Journal of Bacteriology, 195(13):3035-3044 PMC3697545.
• (97) T. Gebregiworgis, C. Massilamany, A. Gangaplara, S. Thulasingam, V. Kolli, M. T. Wertha, E. D. Dodds, D. Steffen, J. Reddy* and R. Powers* (2013) "Potential of Urinary Metabolites for Diagnosing Multiple Sclerosis", ACS Chem. Biol., 8(4):684-690 PMC3631445.
• (96) B. Worley, and R. Powers* (2013) "Multivariate Analysis in Metabolomics", Current Metabolomics, 1(1):92-107 PMC44651877.
• (95) B. Worley, S. Halouska and R. Powers* (2013) "Utilities for Quantifying Separation in PCA/PLS-DA Scores", Anal. Biochem., 433(2):102-104 PMC3534867.

2012

• (94) N. V. Chaika,T. Gebregiworgis, M. E. Behrens, P. Radhakrishnan, B. Zhang, X. Liu, V. Purohit, K. Mehla, T. Caffrey, F. Yu, K. R. Johnson, R. Powers, M. A. Hollingsworth and P. K. Singh* (2012) "MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer", Proc. Natl. Acad. Sci. U. S. A., 109(34):13787-13792 PMC3427054.
• (93) A. S. Nuxol, S. Halouska, M. R. Sadykov, M. L. Hanke, K. W. Bayles,T. Kielian, R. Powers and P. D. Fey* (2012) "CcpA regulates arginine biosynthesis in Staphyloccus aureus through repression of proline catabolism", PLoS Pathogens, 8(11):e1003033 PMC3510247.
• (92) J. C. Copeland, L. J. Zehr, R. Cerny, and R. Powers* (2012) "The applicability of molecular descriptors for designing an electrospray ionization mass spectrometry compatible library for drug discovery", Comb. Chem. High Throughput Screening, 15(10):806-815 PMC6645700.
• (91) B. Zhang and R. Powers* (2012) "Analysis of bacterial biofilms using NMR-based metabolomics", Future Med. Chem., 4(10):1273-1306 PMC3564560.
• (90) T. Gebregiworgis and R. Powers* (2012) "Application of NMR Metabolomics to Search for Human Disease Biomarkers", Comb. Chem. High Throughput Screening, 15(8):595-610 PMC6625354.
• (89) D. K. Zinniel, R. J. Fenton, S. Halouska, R. Powers*, R. G. Barletta* (2012) "Sample Preparation of Mycobacterium tuberculosis Extracts for Nuclear Magnetic Resonance (NMR) Metabolomic Studies", Journal of Visualized Experiments, 67:e3673 PMC3485063.
• (88) B. Worley, G. Richard, G. S. Harbison and R. Powers* (2012) "¹³C NMR Reveals No Evidence of n - π* Interactions in Proteins", PLoS ONE, 7(8):e42075 PMC3410932.
• (87) S. Halouska, R. J. Fenton, R. G. Barletta and R. Powers* (2012) "Predicting the in vivo Mechanism of Action for Drug Leads Using NMR Metabolomics", ACS Chem. Biol., 7(1):166-171 PMC3262886.
• (86) M. D. Shortridge, M. A. Griep and R. Powers* (2012) "¹H, ¹³C, and ¹⁵N NMR Assignments for the Helicase Interaction Domain of Staphylococcus aureus DnaG Primase", Biomol. NMR Assign., 6(1):35-38 PMC6690350.

2011

• (85) B. Zhang, S. Halouska, C. E. Sciaffo, M. R. Sadykov, G. A. Somerville and R. Powers* (2011) "NMR Analysis of a Stress Response Metabolic Signaling Network", J. Proteome Res., 10(8):3743-3754. PMC3153081.
• (84) B. Zhang, J. Hodgson, W. Hancock and R. Powers* (2011) "An Inexpensive High-Throughput NMR Tube Cleaning Apparatus", Anal. Biochem., 416(2):234-236. PMC3138807.
• (83) D. S. Hage*, E. D. Dodds, L. Du, and R. Powers (2011) "Research in Bioanalysis and Separations at the University of Nebraska-Lincoln.", Bioanalysis, 3(10):1065-1076. PMC3134374.
• (82) M. D. Shortridge, M. Bokemper, J. L. Stark, J. C. Copeland, and R. Powers* (2011) "Correlation Between Protein Function and Ligand Binding Profiles", J. Proteome Res., 10(5):2538-2545. PMC3090486.
• (81) J. L. Stark, and R. Powers* (2011) "Application of NMR and Molecular Docking in Structure-based Drug Discovery", Topics in Current Chemistry: NMR of Proteins and Small Molecules, pp 1-34. PMC6628936.
• (80) M. D. Shortridge, T. Triplet, P. Revesz, M. Griep and R. Powers* (2011) "Bacterial Protein Structures Reveal Phylum Dependent Divergence", Comput. Biol. Chem., 35:24-33. PMC3049983.
• (79) R. Powers*, J. C. Copeland, J. Stark, A. Caprez, A. Guru, and D. Swanson (2011) "Searching the Protein Structure Database for Ligand-Binding Site Similarities Using CPASS v.2", BMC Research Notes, 4:17. PMC3057182.
• (78) M. D. Shortridge and R. Powers* (2011) "NMR Screening Methods for Drug Discovery in Advances in Biomedical Spectroscopy V.3, Biomolecular NMR Spectroscopy", Andrew Dingley and Steve Pascal, eds., IOS Press, Fairfax, VA, pp. 381-412.

2010

• (77) M. R. Sadykov, B. Zhang, S. Halouska, J. L. Nelson, L. W. Kreimer,Y. Zhu, R. Powers*, and G A. Somerville* (2010) "Using NMR metabolomics to investigate tricarboxylic acid cycle dependent signal transduction in Staphylococcus epidermidis", J. Biol. Chem., 285(47):36616-24. PMC2978590.
• (76) J. Stark, K. A. Mercier, G. A. Mueller, T. B. Acton, R. Xiao, G. T. Montelione, R. Powers* (2010) "Solution structure and function of yndB, an AHSA1 protein from Bacillus subtilis", Proteins, 78(16):3328-3340. PMC20818668.
• (75) T. Triplet, M. D. Shortridge, M. A. Griep, R. Powers* and P. Revesz* (2010) "PROFESS: A PROtein Function, Evolution, Structure and Sequence database", Database, 2010:baq011. PMC20624718.
• (74) M. T. Werth, S. Halouska, M. D. Shortridge, B. Zhang and R. Powers* (2010) "Analysis of Metabolomic PCA Data using Tree Diagrams", Anal. Biochem., 399(1):58-63. PMC2824058.

2009

• (73) R. Powers* (2009) "Advances in Nuclear Magnetic Resonance for Drug Discovery", Expert Opin. Drug Discovery, 4(10):1-22 PMC2843924.
• (72) M. D. Shortridge and R. Powers* (2009) "Structural and Functional Similarity between the Bacterial Type III Secretion System Needle Protein PrgI and the Eukaryotic Apoptosis Bcl-2 Proteins", PLoS ONE, 4(10):1-10. PMC2757720 [Highlighted by Faculty 1000].
• (71) K. A. Mercier, G. A. Mueller, T. B. Acton, R. Xiao, G. T. Montelione, and R. Powers* (2009) "¹H, ¹³C, and ¹⁵N NMR assignments for the Bacillus subtilis yndB START domain", Biomol. NMR Assign., 3(2):191-194. PMC4991356.
• (70) R. Powers* (2009) "NMR Metabolomics and Drug Discovery", Magn. Reson. Chem., 47:S2-S11. PMID19504464 [Most Accessed].
• (69) G. T. Montelione, C. Arrowsmith, M. E. Girvin, M. A. Kennedy, J. L. Markley, R. Powers, J. H. Prestegard, and T. Szyperski (2009) "Unique Opportunities for NMR Methods in Structural Genomics", J. Struct. Funct. Genomics, 10:101-106. PMC2705713.
• (68) K. A. Mercier, J. R. Cort, M. Kennedy, E. E. Lockert, S. Ni, M. D. Shortridge, and R. Powers* (2009) "Structure and Function of Pseudomonas aeruginosa protein PA1324 (21-170)", Prot. Sci., 18(3):606-618. PMC19241370.
• (67) K. A. Mercier, M. D. Shortridge and R. Powers* (2009) "A Multi-Step NMR Screen for the Identification and Evaluation of Chemical Leads for Drug Discovery", Comb. Chem. High Throughput Screening, 12(3):285-295. PMC19275534.
• (66) S. Halouska, Y. Zhou, D. F. Becker and R. Powers* (2009) "Solution Structure of the Pseudomonas putida protein PpPutA45 and its DNA Complex", Proteins, 73:12-27. PMC18767154.

2008

• (65) M.R. Sadykov, M. E. Olson, S. Halouska, Y. Zhu, P. D. Fey, R. Powers and G. A. Somerville (2008) "Tricarboxylic acid cycle dependent regulation of Staphylococcus epidermidis polysaccharide intercellular adhesin synthesis", J. Bacteriol., 130(23):7621-7632. PMC2583607.
• (64) M. D. Shortridge, D. S. Hage, G. S. Harbison and R. Powers* (2008) "Estimating Protein-Ligand Binding Affinity using High-Throughput Screening by NMR", J. Comb. Chem., 10(6):948-958. PMC2631241.
• (63) J. Stark and R. Powers* (2008) "Rapid Protein-Ligand Costructures Using Chemical Shift Perturbations", J. Amer. Chem. Soc., 130(2):535-545. PMC18088118.
• (62) R. Powers*, J. Copeland and K. Mercier (2008) "The Application of FAST-NMR for the Identification of Novel Drug Discovery Targets", Drug Discov. Today, 13(3-4):172-179. PMC18275915.

2007

• (61) R. Powers* (2007) "Functional Genomics and NMR Spectroscopy", Comb. Chem. High Throughput Screening, 10(8):676-697. PMID18045080.
• (60) S. Halouska, O. Chacon, R. Fenton, D. Zinniel, R. G. Barletta, and R. Powers* (2007) "Use of NMR Metabolomics to Analyze the Targets of D-cycloserine in Mycobacteria: Role of D-Alanine Racemase", J. Proteome Res., 6(12):4608-4614. PMC2566856.
• (59) X. Huang, R. Powers, A. Tymiak, R. Espina, and V. Roongta (2007) "Introduction to NMR and its Application in Metabolite Structure Determination in Drug Metabolism in Drug Design and Development: Basic Concepts and Practice", D. Zhang, M. Zhu, and W. G. Humphreys ed., Wiley, Hoboken, NJ, ISBN: 978-0-471-73313-3.

2006

• (58) K. A. Mercier, M. Baran, V. Ramanathan, P. Revesz, R. Xiao, G. T. Montelione and R. Powers* (2006) "FAST-NMR - Functional Annotation Screening Technology Using NMR", J. Amer. Chem. Soc., 128(47):15292-15299. PMC2529462.
• (57) P. Forgue, S. Halouska, M. Werth, K. Xu, S. Harris and R. Powers* (2006) "NMR Metabolic Profiling of Aspergillus nidulans to Monitor Drug and Protein Activity", J. Proteome Res., 5(8):1916-1923. PMID16889413.
• (56) K. A. Mercier, K. Germer and R. Powers* (2006) "Design and Characterization of a Functional Library for NMR Screening against Novel Protein Targets", Comb. Chem. High Throughput Screening, 9(7):515-534. PMID16925512.
• (55) R. Powers*, J. Copeland, K. Germer, K. A. Mercier, V. Ramanathan and P. Revesz (2006) "Comparison of Protein Active-Site Structures for Functional Annotation of Proteins and Drug Design", Proteins, 65(1):124-135. PMID16862592.
• (54) Y-J., Huang, R. Tejero, R. Powers and G. T. Montelione (2006) "A topology-constrained distance network algorithm for protein structure determination from NOESY data", Proteins, 62(3):587-603. PMID16374783.
• (53) S. Halouska and R. Powers* (2006) "Negative Impact of Noise on the Principal Component Analysis of NMR Data", J. Magn. Reson., 178(1):88-95. Supplement. PMID16198132.
• (52) R. Powers and M. M. Siegel (2006) Applications of Nuclear Magnetic Resonance and Mass Spectrometry to Anticancer Drug Discovery, Novel Anticancer Agents: Strategies for Discovery and Clinical Testing, A. A. Adjei and J. K. Buolamwini, eds., Elsevier Science, New York, NY, ISBN: 0-12-088561-1.

2005

• (51) V. Ramanathan, K. A. Mercier, R. Powers, and P. Revesz (2005) "Using Databases and Computational Techniques to Infer the Function of Novel Proteins", 2005 IEEE International Conference on Electro Information Technology, (On CD, collection of reviewed papers).
• (50) R Powers,* N. Mirkovic, S. Goldsmith-Fischman, T. B. Acton, Y. Chiang, J. Y. Huang, L. Ma, P. K. Rajan, J. R. Cort M. A. Kennedy, J. Liu, L. Ma, B. Rost, B. Honig, D. Murray, and G. T. Montelione (2005) "Solution Structure of Archaeglobus fulgidis Peptidyl-tRNA Hydrolase (Pth2) Provides Evidence for an Extensive Conserved Family of Pth2 Enzymes in Archea, Bacteria and Eukaryotes", Prot. Sci., 14(11):2849-2861 (cover). PMC2253226.
• (49) Y. J. Huang, R. Powers, and G. T. Montelione (2005) "Protein NMR Recall, Precision, and F-measure Scores (RPF scores): Structure Quality Assessment Measures Based on Information Retrieval Statistics", J. Amer. Chem. Soc., 127(6):1665-1674. PMID15701001.
• (48) Y. J. Huang, H. Moseley, M. C. Baran, C. Arrowsmith, R. Powers, R. Tejero, T. Szyperski, and G. T. Montelione (2005) "An Integrated Platform for Automated Analysis of Protein NMR Structures", Method. Enzymol., 394:111-141. PMID15808219.
• (47) K. A. Mercier and R. Powers* (2005) "Determining the Optimal Size of Small Molecule Mixtures for High Throughput NMR Screening", J. Biomol. NMR, 31(3):243-258. PMID15803397.

2004

• (46) R. Powers*, T. B. Acton, Y. Chiang, R. Paranji, J. R. Cort, M. A. Kennedy, J. Liu, L. Ma, B. Rost and G. T. Montelione (2004) "Letter to the Editor: ¹H, ¹³C and ¹⁵N Assignments for the Archaeglobus fulgidis Protein AF2095", J. Biomol. NMR, 30:107-108. PMID15452442.
• (45) D. Shao, T. J. Berridon, E. Manas, D. Hauze, R. Powers, A. Bapat, D. Gonder, R. C. Winneker and D. Frail (2004) "Identification of Novel Estrogen Receptor a Antagonists", J. Steroid biochem Mol. Biol, 88(4-5):351-360. PMID15145444.
• (44) T. Rush III and R. Powers* (2004) "The Application of X-ray, NMR and Molecular Modeling in the Design of MMP Inhibitors", Current Topics in Medicinal Chemistry, 4 (12):1311-1327. PMID15320728.

2002

• (43) F. J. Moy, P. K. Chanda, J. Chen, S. Cosmi, W. Edris, J. I. Levin, J. Wilhelm and R. Powers* (2002) "Impact of Mobility on Structure-Based Drug Design for the MMPs", J. Amer. Chem. Soc., 124(43):12658-12659. PMID12392402.
• (42) R. Powers* (2002) "Applications of NMR to Structure Based Drug Design in Structural Genomics", J. Struct. Funct. Genomics, 2:113-123. PMID12836668.

2001

• (41) F. J. Moy, E. Diblasio, J. Wilhelm and R. Powers* (2001) "Solution Structure of Human IL-13 and Implication for Receptor Binding", J. Mol. Biol., 310(1):219-230 PMID11419948.
• (40) J. I. Levin, M. T. Du, J. F. DiJoseph, L. M. Killar, A. Sung, A, T. Walter, M. A. Sharr, C. E. Roth, F. J. Moy, R. Powers, G. Jin, R. Cowling, J. S. Skotnicki (2001) "The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position", Bioorg. Med. Chem. Lett., 11(2):235-238. PMID11206467.
• (39) X. Huang and R. Powers* (2001) "Validity of Using the Radius of Gyration as a Constraint in NMR Protein Structure Determination", J. Amer. Chem. Soc., 123(16):3834-3835. PMID11457122.
• (38) G.-Y. Xu, A. Tam, L. Lin and R. Powers* (2001) "Solution Structure of B. subtillis Acyl carrier protein", Structure, 9(4):277-287. PMID11525165.
• (37) S. F. Sukits, L.-L. Lin, S. Hsu, K. Malakian, R. Powers and G. Y. Xu (2001) "The solution Structure of the Tumor Necrosis Factor Receptor-1 Death Domain", J. Mol. Biol., 310(4):895-906. PMID11453696.
• (36) F. J. Moy, K. Haraki, D. Mobilio, G. Walker K. Tabei, H. Tong, M. M. Siegel and R. Powers* (2001) "MS/NMR: A Structure Based Approach for Discovering Protein Ligands and for Drug Design by Coupling Size-exclusion Chromatography, Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy", Anal. Chem., 73(3):571-581. PMID11217765.

2000

• (35) X. Huang, F. J. Moy, and R. Powers* (2000) "Evaluation of the Utility of NMR Structures Determined from Minimal NOE Based Restraints for Structure Based Drug Design, using MMP-1 as an Example", Biochemistry, 39(44):13365-13375. PMID11063573.
• (34) F. J. Moy, P. K. Chanda, J. M. Chen, S. Cosmi, W. Edris, J. I. Levin and R. Powers* (2000) "High-Resolution Solution Structure of the Catalytic Fragment of Human Collagenase-3 (MMP-13) Complexed with a Hydroxamic acid Inhibitor", J. Mol. Biol., 302(3):673-691. PMID10986126.
• (33) J. M. Chen, J. I. Levin, D. Mobilio, F. J. Moy, F. C. Nelson, R. Nilakantan, Arie Z. and R. Powers* (2000) "Structure Based Design of a Novel, Potent and Selective Inhibitor for MMP-13 Utilizing NMR Spectroscopy and Computer Aided Molecular Design", J. Amer. Chem. Soc., 122(40):9648-9654.
• (32) J.-B. Telliez, G.-Y. Xu, J. Woronicz, S. Hsu, L. Lin, S. F Sukits, R. Powers and L.-L. Lin (2000) "Mutational Analysis and NMR studies of the Death Domain of the Tumor Necrosis Factor Receptor 1", J. Mol. Biol., 300(5):1323-1333. PMID10903872.
• (31) S. A. Desai, X. Wang, E. J. Noronha, Q. Zhou, V. Rebmann, H. Grosse-Wilde, F. J. Moy, R. Powers, and S. Ferrone (2000) "Structural Relatedness of Distinct Determinants Recognized by Monoclonal Antibody TP25.99 on β-2-Microglobulin-associated and β-2-microglobulin-free HLA Class I Antigens", Journal of Immunology, 165(6):3275-3283. PMID10975844.
• (30) F. J. Moy, S. A. Desai, X. Wang, E. J. Noronha, Q. Zhou, S. Ferrone, R. Powers* (2000) "Analysis by NMR Spectroscopy of mAb TP25.99 Defined Linear and Conformational Determinant on HLA Class I Antigen", J Biol Chem, 275(32):24679-24685. PMID10825172.
• (29) F. J. Moy, E. Glasfeld, L. Mosyak and R. Powers* (2000) "Solution Structure of ZipA, a Crucial Component of E. coli Cell Division", Biochemistry, 39(31):9146-9156. PMID10924108.
• (28) F. J. Moy, P. K. Chanda, S. Cosmi, W. Edris J. I. Levin and R. Powers* (2000) "¹H, ¹⁵N, ¹³C, and ¹³CO Assignments and Secondary Structure Determination of Collagenase-3 (MMP-13) Complexed with a Hydroxamic Acid Inhibitor", J. Biomol. NMR, 17(3):269-270. PMID10959634.
• (27) F. J. Moy, E. Glasfeld and R. Powers* (2000) "¹H, ¹⁵N, ¹³C, and ¹³CO Assignments and Secondary Structure Determination of ZipA", J. Biomol. NMR, 17(3):275-276. PMID10959637.
• (26) F. J. Moy, P. K. Chanda, M. I. Cockett, W. Edris, P. G. Jones, K. Mason, S. Semus and R. Powers* (2000) "NMR Structure of Free RGS4 Reveals an Induced Conformational Change Upon Binding Ga", Biochemistry, 39(24):7063-7073. PMID10852703.

1999

• (25) F. J. Moy, P. K. Chanda, M. I. Cockett, W. Edris., P. G. Jones, and R. Powers* (1999) "¹H, ¹⁵N, ¹³C, and ¹³CO Assignments and Secondary Structure Determination of RGS4", J. Biomol. NMR, 15:339-340. PMID10685342.
• (24) F. J. Moy, P. K. Chanda, J. M. Chen, S. Cosmi, W. Edris, J. S. Skotnicki, J. Wilhelm and R. Powers* (1999) "NMR Solution Structure of the Catalytic Fragment of Human Fibroblast Collagenase Complexed with a Sulfonamide Derivative of a Hydroxamic Acid Compound", Biochemistry, 38(22):7085-7096. PMID10353819.
• (23) R. Tejero, D. Monleon, B. Celda, R. Powers and G. T. Montelione (1999) "HYPER: A Hierarchical Algorithim Involving Progressive Application of Conformational Constraints For Automatic Determination of Protein Dihedral-Angle Constraints and CβH₂ Methylene Resonance Assignments from NMR Data", J. Biomol. NMR, 15:251-264. PMID10677828.

1998

• (22) D. Kitchen, R. C. Hoffman, F. J. Moy, and R. Powers* (1998) "Homology Model for Oncostatin M Based on NMR Structural Data", Biochemistry, 37(30):10581-10588. PMID9692947.
• (21) F. J. Moy, P. K. Chanda, C. Urbano, M. R. Pisano, J. Wilhelm, and R. Powers* (1998) "High-Resolution Solution Structure of the Inhibitor-Free Catalytic Fragment of Human Fibroblast Collagenase", Biochemistry, 37(6):1495-1504. PMID9484219.

1997

• (20) F. J. Moy, M. R. Pisano, P. K. Chanda, C. Urbano, L. M. Killar, M.-L. Sung and R. Powers* (1997) "Assignments, Secondary Structure and Dynamics of the Inhibitor-Free Catalytic Fragment of Human Fibroblast Collagenase", J. Biomol. NMR, 10:9-19. PMID9335112.
• (19) D. E. Zimmerman, C. A. Kulikowski, W. Feng,M. Tashiro, C.-Y. Chien, C. B. Rios, F. J. Moy, R. Powers, G. T. Montelione (1997) "Automated Analysis of Protein NMR Assignments Using Methods from Artificial Intelligence", J. Mol. Biol., 269:592-610. PMID9217263.
• (18) F. J. Moy, M. Safran, A. P. Seddon, D. Kitchen, P. Bohlen, D. Aviezer, A. Yayon, and R. Powers* (1997) "Properly Oriented Heparin-Decasaccharide Induced Dimers are the Biological Active Form of Basic Fibroblast Growth Factor", Biochemistry, 36(16):4782-4791. PMID9125499.

1996

• (17) F. J. Moy, A. P. Seddon, P. Bohlen and R. Powers* (1996) "High-Resolution Solution Structure of Basic Fibroblast Growth Factor Determined by Multidimensional Heteronuclear Magnetic Resonance Spectroscopy", Biochemistry, 35(42):13552-13561. PMID8885834.
• (16) R. C. Hoffman, F. J. Moy, V. Price, J. Richardson, D. Kaubisch, E. A. Frieden, J. D. Krakover, B. J. Castner, J. King, C. J. March, and R. Powers* (1996) "Resonance Assignments for Oncostatin M: a 24 kDa α-Helical Protein", J. Biomol. NMR, 7:273-282. PMID8765735.

1995

• (15) F. J. Moy, A. P. Seddon, E. B. Campbell, P. Bhlen and R. Powers* (1995) "¹H, ¹⁵N, ¹³C, and ¹³CO Assignments and Secondary Structure Determination of Basic Fibroblast Growth Factor Using Three-Dimensional Heteronuclear Magnetic Resonanc Spectroscopy", J. Biomol. NMR, 6:245-254. PMID8520218.

1993

• (14) R. Powers, G. M. Clore, D. S. Garrett, and A. M. Gronenborn (1993) "Relationship between the Precision of High-Resolution Protein NMR Structures, Solution-Order Parameters, and Crystallographic B Factors", Journal of Magnetic Resonance, Series B, 101(3):325-327.
• (13) R. Powers, D. S. Garrett, C. J. March, E. A. Frieden, A. M. Gronenborn, and G. Marius Clore (1993) "The High-Resolution, Three-Dimensional Solution Structure of Human Interleukin-4 Determined by Multidimensional Heteronuclear Magnetic Resonance Spectroscopy", Biochemistry, 32(26):6744-6762. PMID8329398.
• (12) G. W. Vuister, G.M. Clore, A. M. Gronenborn, R. Powers, D. S. Garrett, R. Tschudin, A. Bax (1993) "Increased Resolution and Improved Spectral Quality in Four-Dimensional ¹³C/¹³C-Separated HMQC-NOESY-HMQC Spectra Using Pulsed Field Gradients", J. Magn. Reson., Series B., 101(2):210-213.

1992

• (11) R. Powers, G. M. Clore*, and A. M. Gronenborn* (1992) "Analysis of the Backbone Dynamics of the Ribonuclease H Domain of the Human Immunodeficiency Virus Reverse Transcriptase by Two-Dimensional Inverse Detected Heteronuclear ¹⁵N-¹H NMR Spectroscopy", Biochemistry, 31(38):9150-9157. PMID1382587.
• (10) R. Powers, D. S. Garrett, C. J. March, E. A. Frieden, A. M. Gronenborn*, and G. M. Clore* (1992) "Three-Dimensional Solution Structure of Human Interleukin-4 by Multi-Dimensional Heteronuclear Magnetic Resonance Spectroscopy", Science, 256:1673-1677. PMID1609277.
• (9) D. S. Garrett, R. Powers, C. J. March, E. A. Frieden, G. M. Clore*, and A. M. Gronenborn* (1992) "Determination of the Secondary Structure and Folding Topology of Human Interleukin-4 using Three-Dimensional Heteronuclear Magnetic Resonance Spectroscopy", Biochemistry, 31(17):4347-4353. PMID1567881.
• (8) R. Powers, D. S. Garrett, C. J. March, E. A. Frieden, A. M. Gronenborn*, and G. M. Clore* (1992) "¹H, ¹⁵N, ¹³C, and ¹³CO Assignments of Human Interleukin 4 using Three-Dimensional Double and Triple Resonance Heteronuclear Magnetic Resonance Spectroscopy", Biochemistry, 31(17):4334-4346. PMID1567880.

1991

• (7) D. S. Garrett, R. Powers, A. M. Gronenborn*, and G. M. Clore* (1991) "A Common Sense Approach to Peak Picking Two-, Three- and Four-Dimensional Spectra using Automatic Computer Analysis of Contour Diagrams", J. Magn. Reson., 95:214-220.
• (6) R. Powers, G. M. Clore*, A. Bax, D. S. Garrett, S. J. Stahl, P. T. Wingfield, and A. M. Gronenborn* (1991) "Secondary Structure of the Ribonuclease H Domain of the Human Immunodeficiency Virus Reverse Transcriptase in Solution using Three-Dimensional Double and Triple Resonance Heteronuclear Magnetic Resonance Spectroscopy", J. Mol. Biol., 221:1081-1090. PMID1719214.
• (5) R. Powers, A. M. Gronenborn, G. M. Clore, and A. Bax* (1991) "Three-Dimensional Triple Resonance NMR of ¹³C/¹⁵N Enriched Proteins using Constant-Time Evolution", J. Magn. Reson., 94:209-213.

1990

• (4) R. Powers and D. G. Gorenstein* (1990) "Two-Dimensional ¹H and ³¹P NMR Spectra and Restrained Molecular Dynamics Structure of a Covalent CPI-CDPI₂ Oligodeoxyribonucleotide Decamer Complex", Biochemistry, 29(42):9994-10008. PMID2271635.
• (3) R. Powers, C. R. Jones, and D. G. Gorenstein* (1990) "Two-Dimensional ¹H and ³¹P NMR Spectra and Restrained Molecular Dynamics Structure of an Oligodeoxyribonucleotide Duplex Refined via a Hybrid Relaxation Matrix Procedure", Journal of Biomolecular Structure & Dynamics, 8(2):253-294. PMID2268403.

1989

• (2) R. Powers, R. K. Olsen, and D. G. Gorenstein* (1989) "Two-Dimensional ¹H and ³¹P NMR Spectra of a Decamer Oligodeoxyribonucleotide Duplex and a Quinoxaline ([N-MeCys 3, N-MeCys 7]TANDEM) Drug Duplex Complex", Journal of Biomolecular Structure & Dynamics, 7(3):515-556. PMID2627298.
• (1) V. Roongta, R. Powers, C. Jones, J. Shields, and D. G. Gorenstein* (1989) "Solution Conformation of a Synthetic Fragment of Human Pituitary Growth Hormone; Two Dimensional NMR of an a-Helical Dimer", Biochemistry, 28(3):1048-1055. PMID2713357.